Preheat the oven to 350°F. Spread the cabbage across the bottom of a 9x13 dish. In a large skillet, cook the ground beef with the chopped onion over medium heat until browned.

Drain excess fat from the skillet. Add rice, chili powder, garlic powder, salt, and pepper to the skillet. Stir in crushed tomatoes and mix well. Spread the meat mixture over the cabbage in the baking dish.

Mix tomato sauce, brown sugar, and vinegar together and pour over the meat and cabbage layers. Cover the dish with foil and bake for 90 minutes. Uncover and let rest for 5-10 minutes before serving.